Description
Product Characteristics:
This gene is thought to function in extracellular matrixremodeling and migration. It is predominantly expressed in theovary, but down regulated in ovarian cancer cell lines and primarycarcinomas, suggesting its role as a tumour suppressor. Mutationsin this gene have been associated with Hennekamlymphangiectasia-lymphedema syndrome, a generalized lymphaticdysplasia in humans. [provided by RefSeq, Mar 2010].
Subcellular location: Secreted
Synonyms: CCBE 1, ccbe1, CCBE1_HUMAN, Collagen and calcium binding EGF domain containing protein 1, Collagen and calcium binding EGF domains 1, Collagen and calcium-binding EGF domain-containing protein 1, Full of fluid protein homolog.
Target Information: This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans. [provided by RefSeq, Mar 2010]